Research library
Skin & CosmeticMaturing human RCT base
Acetyl Hexapeptide-3/8
Argireline, SNAP-25-mimetic hexapeptide
A topical hexapeptide (acetyl hexapeptide-3/8) that interferes with SNARE complex formation, a mild, 'topical Botox like' approach to expression wrinkles.
Ac-EEMQRR
SNAP-25
~30%
How Argireline works
A topical 'Botox like' peptide, far milder than the injectable. It dampens the nerve signal that makes muscles contract, softening expression lines.
Argireline
SNAP-25 mimic
↓ ACh release
Softer lines
Research applications
Expression wrinkles
Crow's feet / forehead
Skin smoothing
Wrinkle depth
Bars indicate how far the evidence has progressed (in vitro to animal to human), not the size of any effect.
Molecular profile
Evidence, safety & status
Claimed benefits & evidence
Targets dynamic expression wrinkles. A 10% emulsion reduced wrinkle depth up to ~30% over 30 days; a 2023 double blind RCT found it and palmitoyl pentapeptide-4 both significantly improved crow's feet. Effect size is modest and penetration dependent.
Safety & dangers
Excellent topical safety; non irritating at high doses.
Regulatory status
OTC cosmetic ingredient. WADA: not prohibited.
Source: Fnx Performance Peptide Research Database, a synthesis of the scientific and regulatory literature, not medical advice. For medical questions, consult a qualified physician.
For research use only
For Research Use Only. Not for human or animal consumption. Products are sold strictly for in vitro laboratory research, not for compounding or therapeutic application.