Research library
Longevity & MitochondrialFDA approved with RCT backed data
SS-31 / Forzinity
Elamipretide, Mitochondria targeting tetrapeptide
A cell permeable tetrapeptide that binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae and improving bioenergetics, the first drug to directly target mitochondria.
Cardiolipin
FDA 2025
How Elamipretide works
A cell permeable peptide that homes to the inner mitochondrial membrane and binds cardiolipin, stabilizing the energy machinery and cutting oxidative stress.
Elamipretide
Mitochondria
Cardiolipin
Bioenergetics
Research applications
Barth syndrome
Mitochondrial disease
Mitochondrial bioenergetics
Cardiolipin stabilization
Longevity / anti aging
Extrapolative
Bars indicate how far the evidence has progressed (in vitro to animal to human), not the size of any effect.
Molecular profile
Key studies
Long term efficacy and safety of elamipretide in Barth syndrome: 168-week open label extension of TAZPOWER
Reid Thompson W, et al.
In the open label extension, elamipretide was well tolerated with sustained improvements in functional assessments and cardiac function.
Evidence, safety & status
Claimed benefits & evidence
FDA accelerated approval (Sept 2025) for Barth syndrome, the first drug to directly target mitochondria. The randomized crossover portion of TAZPOWER (12 subjects) did NOT meet its primary endpoints; approval rested on the open label extension showing improved knee extensor strength. Longevity/anti aging uses are entirely extrapolative.
Safety & dangers
Most common adverse event was injection site reactions (treatable). Continued approval is contingent on verifying clinical benefit.
Regulatory status
FDA approved (rare disease, Stealth BioTherapeutics). In off label/wellness use it would be WADA prohibited under S0.
Administration
Daily subcutaneous (40 mg in trials).
Source: Fnx Performance Peptide Research Database, a synthesis of the scientific and regulatory literature, not medical advice. For medical questions, consult a qualified physician.
For research use only
For Research Use Only. Not for human or animal consumption. Products are sold strictly for in vitro laboratory research, not for compounding or therapeutic application.