Growth Hormone AxisPlausible but unproven in humans

GH releasing peptides

GHRP-2 / GHRP-6 / Hexarelin, Ghrelin mimetic GHRPs

A family of synthetic ghrelin mimetic GH releasing peptides acting on GHS-R1a, varying in GH potency, appetite stimulation, and cortisol/prolactin effect.

GH / IGF-1 Recovery

GHS-R1a

Receptor

Subcutaneous

Route

Cortisol / PRL

Off target rise

Mechanism of action

How GHRP-2 / GHRP-6 / Hexarelin works

A family of synthetic ghrelin mimetic peptides that switch on the GHS-R1a receptor to release growth hormone, with varying appetite and cortisol effects.

GHRP

Ghrelin mimetic

GHS-R1a

Receptor

GH release

Pituitary

↑ IGF-1

+ appetite

Also studied

GHRP-2 is a potent GH releaser; GHRP-6 strongly stimulates appetite; hexarelin is the most potent but desensitizes receptors.

See related compounds

Can raise cortisol and prolactin (more than ipamorelin), with water retention.

See related compounds

Applications

Research applications

GH release

Clinical pharmacology

Human pilot data

Older PK studies

Appetite (GHRP-6)

Stimulation

Animal (rodent) model

Preclinical / anecdote

Bars indicate how far the evidence has progressed (in vitro to animal to human), not the size of any effect.

Full profile

Evidence, safety & status

Claimed benefits & evidence

GH release, appetite (GHRP-6), and recovery are claimed. Human efficacy/safety for anti aging or performance is not established, though older clinical pharmacology studies confirm GH release.

Safety & dangers

Cortisol/prolactin elevation, water retention, IGF-1 mediated theoretical risks, and receptor desensitization (hexarelin).

Regulatory status

Not FDA approved; WADA prohibited (S2, GHRPs including hexarelin, GHRP-2/pralmorelin, and GHRP-6 explicitly named).

Administration

Subcutaneous.

Source: Fnx Performance Peptide Research Database, a synthesis of the scientific and regulatory literature, not medical advice. Anyone considering these compounds should consult a qualified physician.

For research use only

For Research Use Only. Not for human or animal consumption. Products are sold strictly for in vitro laboratory research, not for compounding or therapeutic application.