Longevity & MitochondrialPreclinical / anecdotal

SHLP family

Humanin, Mitochondrial derived peptide

The first identified mitochondrial derived peptide, cytoprotective and anti apoptotic via AKT/ERK/STAT3 signaling in preclinical neuronal and vascular models.

Mitochondria Neuroprotection Insulin sensitivity

First MDP

Discovery

AKT/ERK/STAT3

Signaling

Preclinical

Evidence

How Humanin works

The first mitochondria derived peptide ever discovered, a cytoprotective, anti apoptotic signal studied for shielding neurons and blood vessels.

Humanin

First MDP

AKT/ERK/STAT3

Signaling

Anti apoptotic

Cytoprotection

Neuro + vascular

Protection

Also studied

Research applications

Neuroprotection

Alzheimer's models

Animal (rodent) model

Preclinical

Insulin sensitization

Metabolic

Animal (rodent) model

Preclinical

Cardioprotection

Vascular

Animal (rodent) model

Preclinical

Bars indicate how far the evidence has progressed (in vitro to animal to human), not the size of any effect.

Molecular profile

CAS number330936-69-1

Molecular formulaC119H204N34O32S2

Molecular weight2687.28 g/mol

Type24 aa mitochondrial derived peptide

SequenceMet-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

AppearanceWhite lyophilized powder

Evidence, safety & status

Claimed benefits & evidence

Neuroprotection, insulin sensitization, and cardioprotection, preclinical only. No human therapeutic trials.

Safety & dangers

Unknown in humans.

Regulatory status

Not FDA approved; research chemical; WADA S0.

Source: Fnx Performance Peptide Research Database, a synthesis of the scientific and regulatory literature, not medical advice. For medical questions, consult a qualified physician.

For research use only

For Research Use Only. Not for human or animal consumption. Products are sold strictly for in vitro laboratory research, not for compounding or therapeutic application.