Longevity & MitochondrialPreclinical / anecdotal

SHLP family

Humanin, Mitochondrial derived peptide

The first identified mitochondrial derived peptide, cytoprotective and anti apoptotic via AKT/ERK/STAT3 signaling in preclinical neuronal and vascular models.

Mitochondria Neuroprotection Insulin sensitivity

First MDP

Discovery

AKT/ERK/STAT3

Signaling

Preclinical

Evidence

Mechanism of action

How Humanin works

The first mitochondria derived peptide ever discovered, a cytoprotective, anti apoptotic signal studied for shielding neurons and blood vessels.

Humanin

First MDP

AKT/ERK/STAT3

Signaling

Anti apoptotic

Cytoprotection

Neuro + vascular

Protection

Also studied

Cytoprotective in neuronal models; a humanin derivative reduced amyloid-β and improved memory in an Alzheimer's mouse model.

See related compounds

Preclinical evidence for insulin sensitization and cardioprotection; no human therapeutic trials exist.

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The first identified mitochondrial derived peptide, encoded in the 16S rRNA region of mitochondrial DNA.

See related compounds

Applications

Research applications

Neuroprotection

Alzheimer's models

Animal (rodent) model

Preclinical

Insulin sensitization

Metabolic

Animal (rodent) model

Preclinical

Cardioprotection

Vascular

Animal (rodent) model

Preclinical

Bars indicate how far the evidence has progressed (in vitro to animal to human), not the size of any effect.

Compound data

Molecular profile

CAS number330936-69-1

Molecular formulaC119H204N34O32S2

Molecular weight2687.28 g/mol

Type24 aa mitochondrial derived peptide

SequenceMet-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

AppearanceWhite lyophilized powder

Full profile

Evidence, safety & status

Claimed benefits & evidence

Neuroprotection, insulin sensitization, and cardioprotection, preclinical only. No human therapeutic trials.

Safety & dangers

Unknown in humans.

Regulatory status

Not FDA approved; research chemical; WADA S0.

Administration

Injectable (research).

Source: Fnx Performance Peptide Research Database, a synthesis of the scientific and regulatory literature, not medical advice. Anyone considering these compounds should consult a qualified physician.

For research use only

For Research Use Only. Not for human or animal consumption. Products are sold strictly for in vitro laboratory research, not for compounding or therapeutic application.