Research library
Tissue Repair & RecoveryPreclinical / anecdotal
Lysine Proline Valine
KPV, α MSH C terminal tripeptide
The C terminal tripeptide of α MSH, studied for anti inflammatory activity via NF-κB modulation, without the melanocortin or tanning effects of the parent hormone.
Lys-Pro-Val
NF-κB
Preclinical
How KPV works
The anti inflammatory C terminal piece of α MSH, it calms NF-κB inflammatory signaling inside cells, without the tanning effects of the parent hormone.
KPV
Cell uptake
NF-κB ↓
Mucosal calm
Research applications
Intestinal inflammation
Colitis / IBD models
Anti inflammatory signaling
NF-κB / cytokines
Wound healing
Skin & mucosa
Bars indicate how far the evidence has progressed (in vitro to animal to human), not the size of any effect.
Molecular profile
Key studies
PepT1 mediated tripeptide KPV uptake reduces intestinal inflammation
Dalmasso G, et al.
Oral KPV reduced inflammation in two mouse colitis models via PepT1 mediated uptake, inhibiting NF-κB and pro inflammatory cytokines.
Evidence, safety & status
Claimed benefits & evidence
Anti inflammatory and gut healing claims (IBD, wound healing). Evidence is preclinical; no completed human efficacy trials.
Safety & dangers
Limited human safety data; gray market risk.
Regulatory status
Not FDA approved; Category 2 (2023), removed April 2026; PCAC review July 23, 2026 (wound healing and inflammatory conditions).
Source: Fnx Performance Peptide Research Database, a synthesis of the scientific and regulatory literature, not medical advice. For medical questions, consult a qualified physician.
For research use only
For Research Use Only. Not for human or animal consumption. Products are sold strictly for in vitro laboratory research, not for compounding or therapeutic application.