Research library
Skin & CosmeticMaturing human RCT base
Palmitoyl Pentapeptide-4 / Matrixyl 3000
Matrixyl, Collagen 'signal' peptide
A topical collagen 'signal' peptide (palmitoyl pentapeptide-4) that prompts fibroblasts to synthesize collagen, among the best studied cosmetic peptides.
pal-KTTKS
Collagen I/IV
~36%
How Matrixyl works
A collagen fragment mimic applied topically: it 'tricks' fibroblasts into thinking collagen has broken down, prompting them to build more. One of the best studied cosmetic peptides.
Matrixyl
Fibroblasts
Collagen I & IV ↑
Smoother skin
Research applications
Wrinkle reduction
Collagen synthesis
Skin firmness
Dermal matrix
Anti inflammatory
IL-6 suppression (3000)
Bars indicate how far the evidence has progressed (in vitro to animal to human), not the size of any effect.
Molecular profile
Evidence, safety & status
Claimed benefits & evidence
Among the best studied cosmetic peptides. Multiple double blind, placebo controlled split face trials (e.g., 93 women, 12 weeks) showed reduced wrinkle surface area (up to ~36%), depth, and roughness, comparable to retinol with better tolerability. Caveat: many trials are small and several are manufacturer funded.
Safety & dangers
Very well tolerated; no photosensitivity; suitable for sensitive skin. Topical only, negligible systemic risk.
Regulatory status
OTC cosmetic ingredient (legal). WADA: not prohibited (topical cosmetic).
Source: Fnx Performance Peptide Research Database, a synthesis of the scientific and regulatory literature, not medical advice. For medical questions, consult a qualified physician.
For research use only
For Research Use Only. Not for human or animal consumption. Products are sold strictly for in vitro laboratory research, not for compounding or therapeutic application.