Research library
Cognitive & NeuroprotectiveModest registered trials
Tuftsin analog
Selank, Synthetic heptapeptide
A synthetic heptapeptide analog of tuftsin studied as a non sedating anxiolytic, modulating GABA/serotonin systems and raising BDNF without dependence in studied models.
Tuftsin
GABA / 5-HT
Non sedating
How Selank works
A heptapeptide built from the immune fragment tuftsin, studied as a non sedating anti anxiety agent that works on GABA and serotonin without the dependence of benzodiazepines.
Selank
GABA / 5-HT
↑ enkephalins, BDNF
Anxiolytic
Research applications
Generalized anxiety
Non sedating anxiolytic
Cognition / focus
BDNF support
Immune modulation
Tuftsin lineage
Bars indicate how far the evidence has progressed (in vitro to animal to human), not the size of any effect.
Molecular profile
Key studies
Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia
Zozulia AA, et al.
In 62 patients, Selank's anxiolytic effect was comparable to medazepam but with added antiasthenic effect and no sedation or dependence.
Evidence, safety & status
Claimed benefits & evidence
A Russia registered anxiolytic. Russian RCT type studies report anxiolytic efficacy comparable to benzodiazepines without sedation, dependence, or cognitive impairment; one double blind GAD trial reported larger HAM-A reduction vs placebo. Samples are small and single institution, and comparison to benzodiazepines (rather than first line SSRIs) limits Western relevance.
Safety & dangers
Well tolerated, with no dependence/withdrawal reported; long term/Western data limited.
Regulatory status
Russia registered; not FDA approved. Category 2 (2023); nomination withdrawn Sept 2024; not yet scheduled for PCAC review. WADA: S0.
Source: Fnx Performance Peptide Research Database, a synthesis of the scientific and regulatory literature, not medical advice. For medical questions, consult a qualified physician.
For research use only
For Research Use Only. Not for human or animal consumption. Products are sold strictly for in vitro laboratory research, not for compounding or therapeutic application.